Preferred Label : HER2Bi-Armed Activated T Cells;
NCIt synonyms : Anti-CD3 x Anti-Her2/neu Bispecific Antibody-Armed Activated T Cells; HER2Bi-Armed ATCs;
NCIt definition : Activated T cells (ATC) that have been coated with bispecific antibodies (BiAb), with
potential antineoplastic and immunomodulating activities. In vitro, T cells are activated
through exposure to the anti-CD3 murine monoclonal antibody OKT3 and interleukin 2
for 14 days and then armed with anti-CD3 x anti-Her2 bispecific antibody (Her2Bi).
Upon administration, HER2Bi-armed activated T cells attach to CD3-expressing T cells
and HER2/neu-expressing tumor cells, selectively cross-linking T cells and tumor cells;
this may result in the recruitment and activation of cytotoxic T lymphocyte (CTLs),
CTL perforin-mediated tumor cell cytolysis, and the secretion of antitumor cytokines
and chemokines.;
NCI Metathesaurus CUI : CL413578;
Origin ID : C88317;
UMLS CUI : C2981832;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
