ERB-38 Immunotoxin

Preferred Label : ERB-38 Immunotoxin;

NCIt synonyms : Erb-38;

NCIt definition : A bivalent fusion protein consisting of disulfide-stabilized Fv fragments of an anti-HER2 (erbB2) monoclonal antibody (e23) and a truncated version of the M(r) 38 fragment of Pseudomonas exotoxin that lacks the toxin's cell binding domain. ERB-38 immunotoxin binds specifically to cells that overexpress HER2, the antigenic target of the monoclonal antibody; the exotoxin portion of the immunotoxin then lyses the cells bound by the antibody portion. (NCI04);

Alternative definition : NCI-GLOSS: A toxic substance linked to an antibody that attaches to tumor cells and kills them.;

NSC code : 683039;

Codes from synonyms : CDR0000045572;

Details

Origin ID

C2453;

UMLS CUI

C0677808;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
chemical_or_drug_affects_gene_product
- Elongation Factor 2 [NCIt concept]
- Receptor Tyrosine-Protein Kinase erbB-2 [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Binding [NCIt concept]
- Enzyme Inhibition [NCIt concept]
- Mitochondrial Damage [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Positive Regulation of Apoptosis [NCIt concept]
concept_is_in_subset
- NCI Drug Dictionary Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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