Preferred Label : Nelipepimut-S Plus GM-CSF Vaccine;
NCIt synonyms : NeuVax Plus GM-CSF; E75 Vaccine Plus GM-CSF; HLA A2/A3-Restricted HER-2/neu Peptide Vaccine Plus GM-CSF; E75 Plus GM-CSF; Nelipepimut-S Plus Sargramostim;
NCIt definition : A cancer peptide vaccine comprised of a human leukocyte antigen (HLA) A2/A3 restricted
HER2/neu (ERBB2) peptide from the extracellular domain of the HER2 protein (E75 peptide)
and combined with the immunoadjuvant granulocyte-macrophage colony-stimulating factor
(GM-CSF), with potential immunomodulating and antineoplastic activity. Upon intradermal
injection, nelipepimut-S plus GM-CSF vaccine may induce a specific cytotoxic T-lymphocyte
(CTL) response against HER2/neu-expressing tumor cell types. HER2/neu, a tumor-associated
antigen and a member of the epidermal growth factor receptor family of tyrosine kinases,
is overexpressed in various tumor cell types. GM-CSF potentiates the antitumor immune
response.;
Semantic type(s)