Preferred Label : Neratinib Maleate;
NCIt synonyms : 2-Butenamide, N-(4-((3-chloro-4-(2-pyridinylmethoxy)phenyl)amino)-3-cyano-7-ethoxy-6-quinolinyl)-4-(dimethylamino)-,
(2E)-, (2Z)-2-butenedioate (1:1); HKI-272 Maleate;
NCIt related terms : NERATINIB MALEATE ANHYDROUS;
NCIt definition : The maleate salt form of neratinib, an orally available, quinazoline-based, irreversible
inhibitor of both the receptor tyrosine kinases (RTKs) human epidermal growth factor
receptor 2 (HER2; ERBB2) and human epidermal growth factor receptor (EGFR), with potential
antineoplastic activity. Upon administration, neratinib targets and covalently binds
to the cysteine residue in the ATP-binding pockets of both HER2 and EGFR. This inhibits
their activity and results in the inhibition of downstream signal transduction events,
induces cell cycle arrest, apoptosis and ultimately decreases cellular proliferation
in HER2- and EGFR-expressing tumor cells. EGFR and HER2, RTKs that are mutated or
overactivated in many tumor cell types, play key roles in tumor cell proliferation
and tumor vascularization.;
UNII : 9RM7XY23ZS;
InChIKey : VXZCUHNJXSIJIM-MEBGWEOYSA-N;
CAS number : 915942-22-2;
Drug name : Nerlynx;
NCI Metathesaurus CUI : CL524716;
Origin ID : C136891;
UMLS CUI : C4519542;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- has_free_acid_or_base_form
- has_target
- is_component_of_chemotherapy_regimen
- is_salt_form_of
