" /> Neratinib - CISMeF





Preferred Label : Neratinib;

NCIt synonyms : KI-272; 2-Butenamide, N-(4-((3-chloro-4-(2-pyridinylmethoxy)phenyl)amino)-3-cyano-7-ethoxy-6-quinolinyl)-4-(dimethylamino)-, (2E)-; (2E)-N-(4-((3-chloro-4-((pyridin-2-yl)methoxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide;

NCIt definition : An orally available, 6,7-disubstituted-4-anilinoquinoline-3-carbonitrile irreversible inhibitor of the HER-2 receptor tyrosine kinase with potential antineoplastic activity. Neratinib binds to the HER-2 receptor irreversibly, thereby reducing autophosphorylation in cells, apparently by targeting a cysteine residue in the ATP-binding pocket of the receptor. Treatment of cells with this agent results in inhibition of downstream signal transduction events and cell cycle regulatory pathways; arrest at the G1-S (Gap 1/DNA synthesis)-phase transition of the cell division cycle; and ultimately decreased cellular proliferation. Neratinib also inhibits the epidermal growth factor receptor (EGFR) kinase and the proliferation of EGFR-dependent cells.;

UNII : JJH94R3PWB;

InChIKey : JWNPDZNEKVCWMY-VQHVLOKHSA-N;

CAS number : 698387-09-6;

Molecule name : HKI-272; PB 272; HKI 272; PB-272;

Chemical formula : C30H29ClN6O3;

ChEBI ID : CHEBI:61397;

Codes from synonyms : 350;

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08/05/2025


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