NCIt definition : A humanized recombinant monoclonal antibody directed against the extracellular dimerization
domain of the HER-2 tyrosine kinase receptor. Binding of the antibody to the dimerization
domain of the HER-2 tyrosine kinase receptor protein directly inhibits the ability
of the HER-2 tyrosine kinase receptor protein (the most common pairing partner) to
dimerize with other HER tyrosine kinase receptor proteins; inhibiting receptor protein
dimerization prevents the activation of HER signaling pathways, resulting in tumor
cell apoptosis. (NCI04);
Alternative definition : NCI-GLOSS: A monoclonal antibody that is being studied in the treatment of cancer.
Monoclonal antibodies are produced in the laboratory and can locate and bind to cancer
cells.;
UNII : K16AIQ8CTM;
CAS number : 380610-27-5; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 380610-27-5
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