Preferred Label : Pertuzumab;

NCIt synonyms : rhuMAb2C4; 2C4; 2C4 Antibody; Monoclonal Antibody 2C4; MoAb 2C4; Immunoglobulin G1, Anti-(Human V (Receptor)) (Human-Mouse Monoclonal 2C4 Heavy Chain), Disulfide with Human-Mouse Monoclonal 2C4 Kappa-Chain, Dimer; Omnitarg; Pertuzumab Biosimilar HS627; Pertuzumab Biosimilar HLX11; Pertuzumab Biosimilar EG1206A; Pertuzumab Biosimilar BCD-178; Rhumab 2C4; Pertuzumab Biosimilar TQB2440;

NCIt definition : A humanized recombinant monoclonal antibody directed against the extracellular dimerization domain of the HER-2 tyrosine kinase receptor. Binding of the antibody to the dimerization domain of the HER-2 tyrosine kinase receptor protein directly inhibits the ability of the HER-2 tyrosine kinase receptor protein (the most common pairing partner) to dimerize with other HER tyrosine kinase receptor proteins; inhibiting receptor protein dimerization prevents the activation of HER signaling pathways, resulting in tumor cell apoptosis. (NCI04);

Alternative definition : NCI-GLOSS: A monoclonal antibody that is being studied in the treatment of cancer. Monoclonal antibodies are produced in the laboratory and can locate and bind to cancer cells.;

UNII : K16AIQ8CTM;

CAS number : 380610-27-5;

Drug name : Perjeta;

Molecule name : RO4368451; HS627; HLX11; EG1206A; BCD-178; TQB-2440; TQB 2440;

NSC code : 740102;

Codes from synonyms : CDR0000340934; 400;

Details


Keyword's position in hierarchy(ies) : arborescence

Main resources

You can consult :


https://pgtmsite.files.wordpress.com/2024/01/pertuzumab_position-preliminaire_final.pdf
2014
Canada
drug information
PAX8 Gene Rearrangement
KIT Positive
pertuzumab
NRAS Gene Mutation
SDHB Positive
c-MET Gene Amplification
KRAS Gene Mutation
IDH Gene Family Mutation
Hepatitis C Virus RNA Positive
PAS Positive
FGFR2 Gene Rearrangement
Positive Number
Estrogen Receptor Positive
ANO1 Positive
breast cancer
GNAQ Gene Mutation
FGFR1 Gene Rearrangement
pertuzumab
Human Immunodeficiency Virus Positive
1p/19q Codeletion
HER-2 positive breast cancer
ESR2 Positive
Hepatitis B Virus Surface Antigen Positive
HRAS Gene Mutation
Breast Cancer Therapeutic Procedure
Herero Language
Positive Lymph Node
Positive EBV Test
RET/PTC Rearrangement
FGFR3 Gene Mutation
SDHA Positive
TERT Promoter Mutation
Pertuzumab
MGMT Gene Promoter Methylation
ERG Gene Rearrangement
GNA11 Gene Mutation
Metastatic Malignant Neoplasm in the Breast
breast neoplasms
pertuzumab
ATRX Gene Mutation
ERBB2 Gene Mutation
neoplasm, malignant
Hepatitis B DNA Positive
Hepatitis B Surface Antibody Positive
FGFR3 Gene Rearrangement
BAP1 Gene Mutation
FGFR2 Gene Mutation
PD-L1 Positive
ERBB2 Gene Amplification
CDH1 Gene Mutation
CTNNB1 Gene Mutation
ETV Gene Rearrangement
Progesterone Receptor Positive

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30/05/2025


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