Preferred Label : Zirconium Zr 89 DFO-Pertuzumab;
NCIt synonyms : Zr 89-DFO-pertuzumab; 89Zr-DFO-pertuzumab; (89)Zr-pertuzumab;
NCIt related terms : PERTUZUMAB DEFEROXAMINE ZIRCONIUM ZR-89;
NCIt definition : A radioimmunoconjugate composed of pertuzumab, a humanized recombinant monoclonal
antibody directed against the extracellular dimerization domain of the tyrosine kinase
receptor human epidermal growth factor-2 (HER2; HER-2), and linked, via the chelator
desferrioxamine (DFO), to the radioisotope zirconium Zr 89 (Zr89), with potential
use in imaging of HER-2-expressing tumor cells upon positron emission tomography (PET).
Upon administration of zirconium Zr 89-DFO-pertuzumab, the pertuzumab moiety targets
and binds to HER-2. After binding and internalization into HER-2-expressing tumor
cells, Zr89 facilitates the visualization and detection of HER-2-expressing tumor
cells using PET. This assesses HER2-expression and may predict or evaluate the tumor's
response to certain HER-2-targeting chemotherapeutics.;
UNII : KR4D9O3XRG;
NCI Metathesaurus CUI : CL521743;
Origin ID : C133822;
UMLS CUI : C4524910;
Semantic type(s)
- concept_is_in_subset
- has_target
