Preferred Label : Engineered Toxin Body Targeting HER2 MT-5111;
NCIt synonyms : HER2-targeted ETB MT-5111; Immunotoxin MT-5111; Recombinant Fusion Protein MT-5111; ETB Targeting HER2 MT-5111; Targeted Engineered Toxin Body MT-5111;
NCIt definition : An engineered toxin body (ETB) composed of a single chain variable fragment (scFv)
from an antibody targeting the human epidermal growth factor receptor 2 (HER2; HER-2),
fused to the enzymatically active de-immunized, ribosome-inactivating cytotoxic payload
Shiga-like toxin-A subunit (SLTA), with potential antineoplastic activity. Upon administration,
the scFv moiety of MT-5111 specifically targets and binds to a distinct epitope on
HER2-expressing cells. Upon internalization, the SLTA moiety is released and acts
as an N-glycosidase, which binds to and cleaves an adenine nucleobase in the 28S RNA
component of the 60S subunit of ribosomes and prevents ribosome activity. This inhibits
protein synthesis and leads to apoptosis in HER2-expressing tumor cells. HER2, a tumor-associated
antigen (TAA), is overexpressed in a variety of tumor cell types.;
Molecule name : MT-5111; MT 5111;
NCI Metathesaurus CUI : CL971043;
Origin ID : C162649;
UMLS CUI : C5206720;
Semantic type(s)
- concept_is_in_subset
- has_target
