Tesevatinib - CISMeF

Preferred Label : Tesevatinib;

NCIt synonyms : 4-Quinazolinamine, N-(3,4-dichloro-2-fluorophenyl)-6-methoxy-7-(((3aalpha,5beta,6aalpha)-octahydro-2-methylcyclopenta(c)pyrrol-5-yl)methoxy)-;

NCIt definition : An orally bioavailable small-molecule receptor tyrosine kinase (RTK) inhibitor with potential antineoplastic activity. Tesevatinib binds to and inhibits several tyrosine receptor kinases that play major roles in tumor cell proliferation and tumor vascularization, including epidermal growth factor receptor (EGFR; ERBB1), epidermal growth factor receptor 2 (HER2; ERBB2), vascular endothelial growth factor receptor (VEGFR), and ephrin B4 (EphB4). This may result in the inhibition of tumor growth and angiogenesis, and tumor regression.;

UNII : F6XM2TN5A1;

InChIKey : HVXKQKFEHMGHSL-QKDCVEJESA-N;

CAS number : 781613-23-8; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 781613-23-8 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : XL647; KD019; KD 019; EXEL 7647;

PubMed : 22011666;

Details

Origin ID

C62496;

UMLS CUI

C4086899;

Automatic exact mappings (from CISMeF team)
- XL647 [MeSH concept]
- XL647 [MeSH Supplementary Concept]
- tesevatinib [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
chemical_or_drug_affects_gene_product
- Receptor Tyrosine Kinase [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Receptor Tyrosine Kinase Inhibition [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Inhibition of Cell Proliferation [NCIt concept]
- Positive Regulation of Apoptosis [NCIt concept]
- Signal Transduction Inhibition [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Epidermal Growth Factor Receptor [NCIt concept]
- Receptor Tyrosine-Protein Kinase erbB-2 [NCIt concept]
- Vascular Endothelial Growth Factor Receptor [NCIt concept]

Keyword's position in hierarchy(ies) :

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