NCIt definition : An orally bioavailable small-molecule receptor tyrosine kinase (RTK) inhibitor with
potential antineoplastic activity. Tesevatinib binds to and inhibits several tyrosine
receptor kinases that play major roles in tumor cell proliferation and tumor vascularization,
including epidermal growth factor receptor (EGFR; ERBB1), epidermal growth factor
receptor 2 (HER2; ERBB2), vascular endothelial growth factor receptor (VEGFR), and
ephrin B4 (EphB4). This may result in the inhibition of tumor growth and angiogenesis,
and tumor regression.;