Ex Vivo-Expanded HER2-Specific T CellsNCIt concept
Preferred Label : Ex Vivo-Expanded HER2-Specific T Cells;
NCIt synonyms : HER2 Specific T-Cells; HER2 Specific T-Cell;
NCIt definition : T cells specific for the human epidermal growth factor receptor 2 (HER2) with potential
immunopotentiating activity. T cells directed against HER2, overexpressed on many
tumor cells, are collected from HER2-expressing tumor tissue, expanded ex vivo and,
then re-introduced in the patient. Re-introduction of ex vivo-expanded HER2-specific
T cells may enhance the cytotoxic T cell response against tumor cells overexpressing
HER2, resulting in inhibition of tumor growth.;