" /> Selatinib - CISMeF





Preferred Label : Selatinib;

NCIt synonyms : 4-Quinazolinamine, N-(3-chloro-4-((3-fluorophenyl)methoxy)phenyl)-6-(5-(((2-(methylsulfinyl)ethyl)amino)methyl)-2-furanyl)-;

NCIt definition : An orally bioavailable dual inhibitor of epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (ErbB-2 or HER-2), and an analog of the quinazoline lapatinib, with potential antineoplastic activity. Upon administration, selatinib reversibly blocks phosphorylation of both EGFR and ErbB2, thereby suppressing tumor growth in EGFR/ErbB-2-overexpressing tumor cells. The tyrosine kinases EGFR and ErbB2 have been implicated in the growth of various tumor types.;

UNII : 6TLR8U8O3C;

CAS number : 1275595-86-2;

Molecule name : L-2; L 2;

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29/07/2025


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