Preferred Label : Selatinib Ditosilate;
NCIt definition : An orally bioavailable ditosilate salt form of selatinib, an analog of the quinazoline
lapatinib and dual inhibitor of epidermal growth factor receptor (EGFR) and Human
Epidermal Growth Factor Receptor 2 (ErbB-2 or HER-2), with potential antineoplastic
activity. Upon administration, selatinib reversibly blocks phosphorylation of both
EGFR and ErbB2, thereby suppressing tumor growth in EGFR/ErbB-2-overexpressing tumor
cells. The tyrosine kinases EGFR and ErbB2 have been implicated in the growth of various
tumor types.;
UNII : 6Q2E32HVE7;
CAS number : 1452886-38-2; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1452886-38-2
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G-SRS /a ;
NCI Metathesaurus CUI : CL454151;
Origin ID : C111764;
UMLS CUI : C3828196;
Semantic type(s)
- concept_is_in_subset
- has_target
