NCIt definition : An anti-human epidermal growth factor receptor 2 (HER2)/anti-CD3 bispecific monoclonal
antibody with potential immunostimulatory and antineoplastic activities. Anti-HER2/Anti-CD3
bispecific monoclonal antibody GBR 1302 possesses two antigen recognition sites, one
for HER2, a tyrosine kinase receptor overexpressed by many cancer cell types, and
one for the CD3 complex, a group of T-cell surface glycoproteins that interact with
the T-cell receptor (TCR). Upon administration of GBR 1302, this bispecific monoclonal
antibody simultaneously binds to both CD3-expressing T-cells and HER2-expressing cancer
cells, thereby crosslinking HER2-expressing tumor cells and cytotoxic T-lymphocytes
(CTLs). This may result in potent CTL-mediated lysis of HER2-expressing tumor cells.
HER2 plays a key role in tumor cell proliferation and tumor vascularization.;
Semantic type(s)