" /> Autologous Anti-HER2 CAR-CD28 T Cells - CISMeF





Preferred Label : Autologous Anti-HER2 CAR-CD28 T Cells;

NCIt synonyms : Autologous Anti-HER2 CAR-CD28 T-cells; Autologous Anti-HER2 CAR-CD28-expressing T Cells;

NCIt definition : A preparation of autologous T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) human epidermal growth factor receptor 2 (HER2; ErbB2; HER-2) and coupled to the costimulatory domain of CD28, with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-HER2 CAR-CD28 T cells target and bind to HER2-expressing tumor cells, thereby inducing selective toxicity in HER2-expressing tumor cells. HER2 is overexpressed in a variety of cancer cell types and is associated with increased tumor cell proliferation.;

NCI Metathesaurus CUI : CL1773497;

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12/05/2024


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