NCIt synonyms : Trastuzumab and rHuPH20; Trastuzumab and Hyaluronidase-oysk; Trastuzumab-Hyaluronidase-oysk; Trastuzumab and Recombinant Human Hyaluronidase PH20; Trastuzumab and Hyaluronidase;
NCIt definition : A ready-to-use combination of trastuzumab, a recombinant humanized monoclonal antibody
directed against the human epidermal growth factor receptor 2 (HER2; receptor tyrosine-protein
kinase erbB-2), and hyaluronidase-oysk, a recombinant human hyaluronidase PH20 (rHuPH20),
that may be used for the treatment of HER2-overexpressing breast cancers. Upon subcutaneous
administration, hyaluronidase-oysk temporarily breaks down the hyaluronan barrier,
which decreases viscosity of, and allows trastuzumab to spread rapidly through the
interstitial space. This improves access to lymphatic and capillary vessels and facilitates
the absorption of trastuzumab into the bloodstream. Trastuzumab binds to the extracellular
ligand-binding domain of HER2 and mediates the activation of an antibody-dependent
cell-mediated cytotoxicity (ADCC) against HER2-expressing tumor cells. HER2 is overexpressed
in many adenocarcinomas, particularly breast adenocarcinomas.;