Preferred Label : Anti-HER2-vc0101 ADC PF-06804103;
NCIt synonyms : Antibody-drug Conjugate PF-06804103; Anti-NG-HER2 ADC PF-06804103; Anti-HER2-vcAur0101 ADC PF-06804103; Anti-NG-Her2-vc0101 ADC PF-06804103;
NCIt definition : A proprietary antibody-drug conjugate (ADC) composed of a monoclonal antibody against
human epidermal growth factor receptor 2 (HER2) site-specifically linked, via a protease
cleavable linker, to an analog of dolastatin 10, Auristatin-0101, with potential antineoplastic
activity. Upon administration, anti-HER2-vc0101 ADC PF-06804103 targets HER2 expressed
on tumor cells. Upon binding, internalization and cleavage, Auristatin-0101 binds
to tubulin and inhibits its polymerization, resulting in G2/M phase arrest and apoptosis
of HER2-expressing tumor cells. HER2, a tumor-associated antigen (TAA), is overexpressed
on a variety of cancer cells.;
Molecule name : PF-06804103; PF 06804103;
NCI Metathesaurus CUI : CL539508;
Origin ID : C141420;
UMLS CUI : C4683804;
Semantic type(s)
- concept_is_in_subset
- has_target
