NCIt definition : An antibody-targeted lipidic nano-carrier containing the antineoplastic anthracycline
antibiotic doxorubicin encapsulated within liposomes, and conjugated to a monoclonal
antibody against the human epidermal growth factor receptor 2 (HER2), with potential
antitumor activity. Upon administration of HER2-targeted liposomal doxorubicin hydrochloride
MM-302, the immunoliposome allows for specific delivery of doxorubicin to tumors overexpressing
the HER2 receptor. Once inside the HER2-expressing tumor cells, doxorubicin intercalates
into DNA and interferes with topoisomerase II activity, thereby inhibiting DNA replication
and RNA synthesis. Compared to doxorubicin alone or liposomal doxorubicin, targeted
liposomal delivery of doxorubicin improves efficacy while lowering the toxicity profile.
HER2, a tyrosine kinase receptor, is overexpressed in many cancer cell types.;
Semantic type(s)