NCIt synonyms : Immunoglobulin G1, Anti-(human Neu (Receptor)) (Human-Mus musculus Monoclonal MGAH22
Clone ch4D5 Heavy Chain), Disulfide with Human-Mus musculus Monoclonal MGAH22 Clone
ch4D5 Light Chain, Dimer; Margetuximab-cmkb;
NCIt definition : A Fc-domain optimized IgG monoclonal antibody directed against the human epidermal
growth factor receptor 2 (HER2) with potential immunomodulating and antineoplastic
activities. After binding to HER2 on the tumor cell surface, margetuximab may induce
an antibody-dependent cell-mediated cytotoxicity (ADCC) against tumor cells overexpressing
HER2. HER2, a tyrosine kinase receptor, is overexpressed by many cancer cell types.
Compared to other anti-HER2 monoclonal antibodies, the Fc domain of MGAH22 is optimized
with increased binding to the activating Fcgamma receptor IIIA (CD16A), expressed
on cells such as natural killer (NK) cells and macrophages, thereby mediating an enhanced
ADCC; the Fc domain also shows decreased binding to the inhibitory Fcgamma receptor
IIB (CD32B).;
UNII : K911R84KEW;
CAS number : 1350624-75-7; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1350624-75-7
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