Preferred Label : Technetium Tc-99m-MIRC208;
NCIt synonyms : 99mTc-MIRC208; Technetium Tc 99m-MIRC208;
NCIt definition : A radioconjugate composed of a nanobody directed against human epidermal growth factor
receptor 2 (HER2; EGFR2; ERBB2) that is labeled with technetium Tc 99m, with potential
use as a tracer for HER2-expressing tumors using single photon emission computed tomography/computed
tomography (SPECT/CT). Upon administration of technetium Tc-99m-MIRC208, the anti-HER2
nanobody moiety targets and binds to HER2-expressing tumor cells. This facilitates
both the detection of HER2-expressing tumor cells and the assessment of responses
to HER2-targeting chemotherapeutic agents using SPECT/CT. HER2, a receptor tyrosine
kinase, is overexpressed on the cell surfaces of various tumor cell types; it plays
a key role in tumor cell proliferation and tumor vascularization.;
NCI Metathesaurus CUI : CL1661988;
Origin ID : C179326;
UMLS CUI : C5555613;
Semantic type(s)
- concept_is_in_subset
- has_target
