Sacibertinib - CISMeF

Preferred Label : Sacibertinib;

NCIt synonyms : EGFR/HER2 Inhibitor Hemay022;

NCIt definition : An orally bioavailable, irreversible dual kinase inhibitor of epidermal growth factor receptor (EGFR; ErbB1) and human epidermal growth factor receptor 2 (HER2; EGFR2; ErbB2), with potential antineoplastic activity. Upon oral administration, sacibertinib covalently binds to and inhibits the activity of EGFR and HER2. This prevents EGFR/HER2-mediated signaling, which may induce cell death and inhibit tumor growth in EGFR/HER2-overexpressing tumor cells. The ErbB receptor tyrosine kinase family is involved in key cellular functions, including cell growth and survival. EGFR and HER2 alterations constitutively upregulate kinase activity.;

UNII : K9S2RGS5TK;

CAS number : 1351941-69-9;

Molecule name : Hemay 022; Hemay-022;

NCI Metathesaurus CUI : CL1922244;

Détails

Origin ID

C203119;

UMLS CUI

C5909003;

Semantic type(s)
- Pharmacologic Substance [UMLS semantic type]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Epidermal Growth Factor Receptor [NCIt concept]
- Receptor Tyrosine-Protein Kinase erbB-2 [NCIt concept]

Position du mot-clé dans l'(les) arborescence(s) :

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