Preferred Label : HER2 Inhibitor ZN-A-1041;
NCIt definition : An orally bioavailable inhibitor of the receptor tyrosine kinase human epidermal growth
factor receptor 2 (HER2; ErbB2; HER-2), with potential antineoplastic activity. Upon
oral administration, HER2 inhibitor ZN-A-1041 selectively binds to and inhibits the
activity of HER2. This prevents HER2-mediated signaling and may lead to cell death
in HER2-expressing tumor cells. HER2, a receptor tyrosine kinase overexpressed on
a variety of tumor cell types, plays an important role in tumor cell proliferation
and tumor vascularization.;
Molecule name : ZN-A 1041; ZN-A1041;
NCI Metathesaurus CUI : CL1647948;
Origin ID : C178299;
UMLS CUI : C5554928;
Semantic type(s)
- concept_is_in_subset
- has_target
