Preferred Label : HER2-targeted Liposomal Doxorubicin Hydrochloride HF158K1;
NCIt synonyms : HER2-targeted Doxorubicin-containing Immunoliposome HF158K1; HER2-targeted Liposomal Doxorubicin HCl HF158K1;
NCIt definition : An antibody liposomal formulation containing the hydrochloride (HCl) salt form of
the antineoplastic anthracycline antibiotic doxorubicin encapsulated within liposomes
which contains TL01, a human epidermal growth factor receptor 2 (HER2)-directed trastuzumab
Fab fragment conjugated lipid, with potential antineoplastic activity. Upon administration
of HER2-targeted liposomal doxorubicin HCl HF158K1, the immunoliposome targets and
binds to HER2-expressing tumor cells, thereby allowing for specific delivery of doxorubicin
to tumors overexpressing the HER2 receptor. Once inside the HER2-expressing tumor
cells, doxorubicin intercalates into DNA and interferes with topoisomerase II activity,
thereby inhibiting DNA replication and RNA synthesis. Compared to doxorubicin alone
or liposomal doxorubicin, targeted liposomal delivery of doxorubicin improves efficacy
while lowering the toxicity profile. HER2, a tyrosine kinase receptor, is overexpressed
in many cancer cell types.;
Molecule name : HF 158K1; HF-158K1;
Origin ID : C200828;
concept_is_in_subset
- has_target
