Preferred Label : Cinrebafusp Alfa;
NCIt synonyms : Anti-HER2 Monoclonal Antibody/Anti-CD137 Anticalin Bispecific Fusion Protein PRS-343;
NCIt definition : A bivalent, bispecific fusion protein comprised of an anti-human epidermal growth
factor receptor (HER2) monoclonal antibody linked to a CD137-targeting anticalin with
potential immunostimulatory and antineoplastic activities. Upon administration of
cinrebafusp alfa, CD137 clustering is promoted by bridging CD137-positive T-cells
with HER2-positive tumor cells, leading to the recruitment of tumor antigen-specific
cytotoxic T-lymphocytes (CTLs). This may result in potent CTL-mediated lysis of HER2-expressing
tumor cells. HER2 plays a key role in tumor cell proliferation and tumor vascularization.
CD137 is a costimulatory immunoreceptor and a member of the tumor necrosis factor
receptor superfamily (TNFRSF). Anticalins are synthetic antigen-binding proteins derived
from lipocalins. Structurally dissimilar to antibodies, anticalins are able to bind
to smaller antigens and exhibit improved tissue penetration.;
UNII : 21Z359Z1CV;
CAS number : 2218515-90-1;
Molecule name : PRS-343;
NCI Metathesaurus CUI : CL541381;
Origin ID : C142890;
UMLS CUI : C5446316;
Semantic type(s)
- concept_is_in_subset
- has_target
