Preferred Label : Anti-HER2 Antibody-drug Conjugate DB-1303;
NCIt synonyms : ADC DB-1303; Anti-HER2 ADC DB-1303; DITAC DB-1303;
NCIt definition : An antibody-drug conjugate (ADC) composed of a monoclonal antibody targeting human
epidermal growth factor receptor 2 (EGFR2; HER2; ErbB2) and conjugated to an as of
yet undisclosed cytotoxic agent, with potential antineoplastic activity. Upon administration
of anti-HER2 ADC DB-1303, the antibody moiety targets and binds to HER2 on tumor cell
surfaces. Upon cellular uptake and internalization, the cytotoxic agent inhibits tumor
cell proliferation through an as of yet undisclosed mechanism of action (MoA). HER2,
a tyrosine kinase receptor, is overexpressed by many cancer cell types.;
Molecule name : DB-1303; DB 1303; BNT-323; BNT 323;
NCI Metathesaurus CUI : CL1793053;
Origin ID : C188319;
UMLS CUI : C5706486;
Semantic type(s)
- concept_is_in_subset
- has_target
