Preferred Label : Trastuzumab Pamirtecan;
NCIt synonyms : ADC DB-1303; Anti-HER2 ADC DB-1303; DITAC DB-1303; Anti-HER2 Antibody-drug Conjugate DB-1303;
NCIt definition : An antibody-drug conjugate (ADC) composed of trastuzumab, a humanized monoclonal antibody
targeting human epidermal growth factor receptor 2 (EGFR2; HER2; ErbB2), conjugated,
via a cleavable linker, to the cytotoxic DNA topoisomerase I inhibitor P1003, with
potential antineoplastic activity. Upon administration of trastuzumab pamirtecan,
trastuzumab targets and binds to HER2 expressed on tumor cells. Upon cellular uptake
and internalization, P1003 is released and inhibits DNA topoisomerase 1 activity,
thereby inhibiting DNA replication and resulting in cell cycle arrest and apoptosis
in tumor cells expressing HER2. HER2, a receptor tyrosine kinase that is mutated or
overexpressed in many tumor cell types, plays an important role in tumor cell proliferation
and tumor vascularization.;
UNII : WPL7XBK5KU;
CAS number : 2792722-57-5;
Molecule name : DB-1303; DB 1303; BNT-323; BNT 323;
NCI Metathesaurus CUI : CL1793053;
Origin ID : C188319;
UMLS CUI : C5706486;
Semantic type(s)
- concept_is_in_subset
- has_target
