NCIt definition : A cancer vaccine comprised of multiple synthetic breast cancer peptides and the adjuvant
tetanus toxoid helper peptide emulsified in the adjuvant Montanide ISA-51 with immunopotentiation
activity. Vaccination with this cancer vaccine may elicit a specific cytotoxic T-lymphocyte
response against breast cancer cells. Synthetic breast cancer peptides may stimulate
the immune response against cells that produce breast cancer markers such as erbB2
(HER2/neu) while tetanus toxoid helper peptide binds to class II MHC molecules as
a nonspecific vaccine helper epitope, resulting in a long-term immunopotentiation
by increasing the helper T-cell response. Montanide ISA-51, also known as incomplete
Freund's adjuvant or IFA, is a stabilized water-in-oil emulsion adjuvant containing
mineral oil with mannide oleate added as a surfactant that non-specifically stimulates
cell-mediated immune responses to antigens.;
Semantic type(s)