Preferred Label : Anti-HER2 Antibody-drug Conjugate IBI354;
NCIt synonyms : Anti-HER2 ADC IBI354;
NCIt definition : An antibody-drug conjugate (ADC) composed of a monoclonal antibody directed against
the tumor-associated antigen (TAA) human epidermal growth factor receptor 2 (EGFR2;
HER2; ErbB2) conjugated to a camptothecin derivative, with potential antineoplastic
activity. Upon administration of the anti-HER2 ADC IBI354, the anti-HER2 monoclonal
antibody targets and binds to HER2 expressed on tumor cells. Upon cellular uptake,
the camptothecin derivative inhibits DNA topoisomerase I activity, thereby inhibiting
DNA replication and resulting in cell cycle arrest and tumor cell apoptosis. This
inhibits the proliferation of HER2-expressing tumor cells. HER2, a tyrosine kinase
receptor, is overexpressed by many cancer cell types.;
Molecule name : IBI-354; IBI 354;
NCI Metathesaurus CUI : CL1906424;
Origin ID : C198994;
concept_is_in_subset
- has_target
