NCIt definition : An orally bioavailable and irreversible inhibitor of the receptor tyrosine kinases
(RTKs) epidermal growth factor receptors 1 (EGFR; ErbB1) and 2 (ErbB2; HER2; HER-2),
with potential antineoplastic activity. Upon oral administration, allitinib selectively
and irreversibly binds to and inhibits the activity of both EGFR and HER2, which prevents
signaling mediated by EGFR and HER2. This may inhibit tumor growth and angiogenesis
in tumor cells overexpressing these RTKs. EGFR and HER2 are RTKs that belong to the
EGFR superfamily; they play major roles in both tumor cell proliferation and tumor
vascularization and are overexpressed in many cancer cell types.;
UNII : CX0M5RO7CY;
CAS number : 897383-62-9;
Molecule name : ALS-1306; ALS 1306; AST-1306; AST 1306;