Preferred Label : Indium In 111 CHX-A DTPA Trastuzumab;
NCIt synonyms : 111In-CHX-A-DTPA-Trastuzumab; Indium-CHX-A DTPA-Trastuzumab;
NCIt definition : An indium In 111-labeled trastuzumab with potential use as an imaging agent. Indium
In 111 CHX-A DTPA trastuzumab is chemically conjugated via a bifunctional metal chelator
molecule, 2-(p-isothiocyanatobenzyl)-cyclohexyl-diethylenetriaminepentaacetic acid
(CHX-A DTPA), a backbone-substituted derivative of DTPA. This agent may allow radioimmunolocalization
of HER2-positive cells. Trastuzumab, a recombinant humanized monoclonal antibody that
selectively binds with high affinity to the extracellular domain of human epidermal
growth factor receptor 2 (HER2), may elicit an antibody-dependent cellular cytotoxicity
(ADCC) against tumor cells that overexpress HER2.;
Alternative definition : NCI-GLOSS: A substance being studied in the imaging of breast cancer and some other
types of cancer. It is made by attaching a radioactive substance called indium 111
to the monoclonal antibody trastuzumab (Herceptin). Trastuzumab binds to the human
growth factor receptor 2 (HER2/neu) on some breast cancer cells and on several other
types of cancer cells. Indium In 111 CHX-A DTPA trastuzumab is a type of radioimmunoconjugate.;
NCI Metathesaurus CUI : CL360663;
NSC code : 740377;
Codes from synonyms : CDR0000559139;
Origin ID : C60766;
UMLS CUI : C1881194;
Semantic type(s)
- concept_is_in_subset
- has_target
