Preferred Label : Trastuzumab/MMAF Antibody-drug Conjugate IKS014;
NCIt synonyms : Anti-HER2 ADC FS-1502; Trastuzumab MMAF; ADC FS-1502; Antibody-drug Conjugate FS-1502; Trastuzumab Monomethyl Auristatin F; Trastuzumab/MMAF ADC IKS014;
NCIt definition : An antibody-drug conjugate (ADC) composed of trastuzumab, a humanized monoclonal antibody
targeting the tumor-associated antigen (TAA) epidermal growth factor receptor 2 (EGFR2;
HER2; ErbB2), site-specifically conjugated, via a tumor-selective beta-glucuronide
linker, to the auristatin analog and potent microtubule inhibitor monomethyl auristatin
F (MMAF), with potential antineoplastic activity. Upon administration of trastuzumab/MMAF
ADC IKS014, the trastuzumab moiety targets and binds to HER2 expressed on tumor cells.
Upon binding, internalization and linker cleavage, MMAF is released. MMAF binds to
and inhibits tubulin polymerization, which results in G2/M phase arrest and tumor
cell apoptosis. HER2, a tyrosine kinase receptor, is overexpressed by many cancer
cell types.;
Molecule name : FS 1502; FS-1502; IKS-014; LCB-14; LCB14-0110; IKS 014; LCB 14;
NCI Metathesaurus CUI : CL1406855;
Origin ID : C172821;
UMLS CUI : C5419878;
Semantic type(s)
- concept_is_in_subset
- has_target
