Preferred Label : HER2-targeted Hypoxia-stimulated CAR T Cells;
NCIt synonyms : HypoSti.CAR-HER2 T Cells; Anti-HER2 Hypoxia-stimulated CAR T-cells; HER2 Targeted HypoSti.CAR-T Cells;
NCIt definition : A preparation of T-lymphocytes that have been genetically modified to express a hypoxia-stimulated
chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) human
epidermal growth factor receptor 2 (HER2; ErbB2; HER-2), with potential immunostimulating
and antineoplastic activities. Upon administration, HER2-targeted hypoxia-stimulated
CAR T cells target and bind to HER2-expressing tumor cells, thereby inducing selective
toxicity in HER2-expressing tumor cells. HER2 is overexpressed in a variety of cancer
cell types and is associated with increased tumor cell proliferation. Hypoxia-stimulated
CAR may improve the expansion and survival of the CAR T cells in the hypoxic tumor
microenvironment (TME).;
NCI Metathesaurus CUI : CL1907021;
Origin ID : C200187;
concept_is_in_subset
- has_target
