Preferred Label : HER2 Inhibitor ELVN-002;
NCIt definition : An orally bioavailable, irreversible inhibitor of the receptor tyrosine kinase human
epidermal growth factor receptor 2 (HER2; ErbB2; HER-2), with potential antineoplastic
activity. Upon oral administration, HER2 inhibitor ELVN-002 selectively binds to and
inhibits the activity of HER2 and various HER2 mutants, including Exon 20 insertion
mutations (E20IMs), while not inhibiting wild-type (WT) EGFR. This prevents HER2-mediated
signaling and may lead to cell death in HER2-expressing tumor cells. HER2, a receptor
tyrosine kinase often overexpressed and mutated in a variety of tumor cell types,
plays an important role in tumor cell proliferation and tumor vascularization. By
sparing WT EGFR, ELVN-002 mostly avoids EGFR-related toxicities.;
Molecule name : ELVN-002; ELVN 002;
NCI Metathesaurus CUI : CL1912558;
Origin ID : C192219;
UMLS CUI : C5784989;
Semantic type(s)
- concept_is_in_subset
- has_target
