Preferred Label : HDAC/EGFR/HER2 Inhibitor CUDC-101;
NCIt synonyms : HDAC EGFR HER2 Inhibitor CUDC-101;
NCIt related terms : CUDC-101;
NCIt definition : A multi-targeted, small-molecule inhibitor of histone deacetylase (HDAC), epidermal
growth factor receptor tyrosine kinase (EGFR/ErbB1), and human epidermal growth factor
receptor 2 tyrosine kinase (HER2/neu or ErbB2) with potential antineoplastic activity.
HDAC/EGFR/HER2 inhibitor CUDC-101 inhibits the activity of these three enzymes but
the exact mechanism of action is presently unknown. This agent may help overcome resistance
to inhibition of EGFR and Her2 through a simultaneous, synergistic inhibition of EGFR,
Her2, and HDAC.;
UNII : 1A7Y9MP123;
CAS number : 1012054-59-9; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1012054-59-9
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G-SRS /a ;
Molecule name : CUDC-101;
Origin ID : C78850;
UMLS CUI : C2697532;
Semantic type(s)
- concept_is_in_subset
- has_target
