HDAC/EGFR/HER2 Inhibitor CUDC-101

Preferred Label : HDAC/EGFR/HER2 Inhibitor CUDC-101;

NCIt synonyms : HDAC EGFR HER2 Inhibitor CUDC-101;

NCIt related terms : CUDC-101;

NCIt definition : A multi-targeted, small-molecule inhibitor of histone deacetylase (HDAC), epidermal growth factor receptor tyrosine kinase (EGFR/ErbB1), and human epidermal growth factor receptor 2 tyrosine kinase (HER2/neu or ErbB2) with potential antineoplastic activity. HDAC/EGFR/HER2 inhibitor CUDC-101 inhibits the activity of these three enzymes but the exact mechanism of action is presently unknown. This agent may help overcome resistance to inhibition of EGFR and Her2 through a simultaneous, synergistic inhibition of EGFR, Her2, and HDAC.;

UNII : 1A7Y9MP123;

CAS number : 1012054-59-9;

Molecule name : CUDC-101;

Details

Origin ID

C78850;

UMLS CUI

C2697532;

Semantic type(s)
- Pharmacologic Substance [UMLS semantic type]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Epidermal Growth Factor Receptor [NCIt concept]
- Histone Deacetylase [NCIt concept]
- Receptor Tyrosine-Protein Kinase erbB-2 [NCIt concept]

Keyword's position in hierarchy(ies) :

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