" /> Histone Deacetylase - CISMeF





Preferred Label : Histone Deacetylase;

NCIt related terms : HDAC;

NCIt definition : Histone acetylation and deacetylation alternately exposes and occludes DNA to transcription factors. Histone deacetylation is catalyzed by the histone deacetylases. There are at least 2 classes of HDACs, class I consisting of proteins homologous to yeast Rpd3 (e.g., HDAC1, HDAC2, and HDAC3) and class II consisting of proteins homologous to yeast Hda1 (e.g., HDAC4 and HDAC6). (from OMIM);

Alternative definition : NCI-GLOSS: An enzyme that removes a small molecule called an acetyl group from histones (proteins found in chromosomes). This changes the way the histones bind to DNA and may affect its activity. HDAC inhibitors are being studied in the treatment of cancer.;

Codes from synonyms : CDR0000586370; CDR0000318815;

Details


Keyword's position in hierarchy(ies) : arborescence

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28/04/2024


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