histone deacetylases

Preferred Label : histone deacetylases;

MeSH definition : Deacetylases that remove N-acetyl groups from amino side chains of the amino acids of HISTONES. The enzyme family can be divided into at least three structurally-defined subclasses. Class I and class II deacetylases utilize a zinc-dependent mechanism. The sirtuin histone deacetylases belong to class III and are NAD-dependent enzymes.;

MeSH synonym : hdac proteins; deacetylases, histone; deacetylase, histone; histone deacetylase;

CISMeF synonym : EC 3.5.1.-; proteins, hdac;

MeSH hyponym : histone deacetylase complexes; class I histone deacetylases; class II histone deacetylases; Complexes, Histone Deacetylase; Deacetylase Complexes, Histone;

MeSH Related Number : class I histone deacetylases; class II histone deacetylases; EC 3.5.1.98;

Registry Number MeSH : EC 3.5.1.98;

Related CAS MeSH : EC 3.5.1.98 (Class I histone deacetylases); EC 3.5.1.98 (Class II histone deacetylases);

Wikipedia link : https://en.wikipedia.org/wiki/Histone deacetylase;

Is substance : O;

UNII : EC 3.5.1.98;

Details

Origin ID

D006655;

UMLS CUI

C0019643;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- HDAC9 wt Allele [NCIt concept]
- Histone Deacetylase [NCIt concept]
- Histone Deacetylase 4 [NCIt concept]
- histone deacetylase complex [GO term]
Indexing information
- 3-(1-cinnamyl-1H-1,2,3-triazol-4-yl)-N-hydroxyacrylamide [MeSH Supplementary Concept]
- 3-(1-methyl-4-phenylacetyl-1H-2-pyrrolyl)-N-hydroxypropenamide [MeSH Supplementary Concept]
- 3-(3-(3-(3-chlorophenyl)-3-oxopropenyl)-1-methylpyrrol-2-yl)propenoic hydroxamic acid [MeSH Supplementary Concept]
- 3-(3-(benzofuran-2-carbonyl)phenyl)-N-hydroxyacrylamide [MeSH Supplementary Concept]
- 4-(3-(hydroxyamino)-3-oxoprop-1-enyl)-N-(4-methyl-3-(4-(pyridin-3-yl)thiazol-2-ylamino)phenyl)benzamide [MeSH Supplementary Concept]
- 4-(dimethylamino)-N-(7-(hydroxyamino)-7-oxoheptyl)benzamide [MeSH Supplementary Concept]
- 4-dimethylamino-N-(4-(2-hydroxycarbamoylvinyl)benzyl)benzamide [MeSH Supplementary Concept]
- 4-dimethylamino-N-(5-(2-mercaptoacetylamino)pentyl)benzamide [MeSH Supplementary Concept]
- 5-((6-(3-chlorophenyl)-4-oxo-3H-pyrimidin-2-yl)thio)pentanoic hydroxamic acid [MeSH Supplementary Concept]
- 5-nitroso-8-quinolinol [MeSH Supplementary Concept]
- 7-(4-(3-ethynylphenylamino)-7-methoxyquinazolin-6-yloxy)-N-hydroxyheptanamide [MeSH Supplementary Concept]
- 7-(4-(4-cyanophenyl)phenoxy)heptanohydroxamic acid [MeSH Supplementary Concept]
- 7-phenyl-2,4,6-heptatrienoylhydroxamic acid [MeSH Supplementary Concept]
- ACS2 compound [MeSH Supplementary Concept]
- ACS33 compound [MeSH Supplementary Concept]
- AS 1387392 [MeSH Supplementary Concept]
- AS 1429716 [MeSH Supplementary Concept]
- CG 0006 [MeSH Supplementary Concept]
- CRA 026440 [MeSH Supplementary Concept]
- FR 235222 [MeSH Supplementary Concept]
- HKI 46F08 [MeSH Supplementary Concept]
- KBH A42 [MeSH Supplementary Concept]
- LGP1 compound [MeSH Supplementary Concept]
- N-(2-amino-5-fluorobenzyl)-4-(N-(pyridine-3-acrylyl)aminomethyl)benzamide [MeSH Supplementary Concept]
- N-(2-aminophenyl)-4-((benzyl(2-hydroxyethyl)amino)methyl) benzamide [MeSH Supplementary Concept]
- N-(4-(2-hydroxycarbamoylvinyl)benzyl)-4-pyrrolidin-1-ylbenzamide [MeSH Supplementary Concept]
- N-(6-(2-amino-4-fluorophenylamino)-6-oxohexyl)-4-methylbenzamide [MeSH Supplementary Concept]
- N-hydroxy-2,2-diphenylacetamide [MeSH Supplementary Concept]
- N-hydroxy-3-(2-oxo-1-phenethyl-1,2,5,6-tetrahydropyridin-3-yl)propanamide [MeSH Supplementary Concept]
- N-hydroxy-3-(3-(1H-indole-2-carbonyl)phenyl)acrylamide [MeSH Supplementary Concept]
- N-hydroxy-4-(3-methyl-2-phenylbutyrylamino)benzamide [MeSH Supplementary Concept]
- N-hydroxy-4-(4-phenylbutyrylamino)benzamide [MeSH Supplementary Concept]
- N-hydroxy-5-(4-(3-thioxo-3H-1,2-dithiol-5-yl)phenoxy)pentanamide [MeSH Supplementary Concept]
- N-hydroxy-7-(2-naphthylthio)heptanamide [MeSH Supplementary Concept]
- N-hydroxy-7-(4-(3-thioxo-3H-1,2-dithiol-5-yl)phenoxy)heptanamide [MeSH Supplementary Concept]
- N-hydroxy-9H-xanthene-9-carboxamide [MeSH Supplementary Concept]
- N1-(2-aminophenyl)-N4-(4-methyl-3-(4-(pyridin-3-yl)pyrimidin-2-ylamino)phenyl)terephthalamide [MeSH Supplementary Concept]
- N1-(2-aminophenyl)-N7-phenylheptanediamide [MeSH Supplementary Concept]
- N1-hydroxy-N8-(4-phenoxyphenyl)octanediamide [MeSH Supplementary Concept]
- N2-(2-aminophenyl)-N5-(4-methyl-3-(4-(pyridin-3-yl)pyrimidin-2-ylamino)phenyl)thiophene-2,5-dicarboxamide [MeSH Supplementary Concept]
- O-n-butanoyl-2,3-O-isopropylidenemannofuranoside [MeSH Supplementary Concept]
- OSU-HDAC42 compound [MeSH Supplementary Concept]
- R 306465 [MeSH Supplementary Concept]
- SD-0203 [MeSH Supplementary Concept]
- SD-2007 [MeSH Supplementary Concept]
- benzyl 7-(2-(hydroxyamino)-2-oxoethoxy)-3-(phenethylcarbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate [MeSH Supplementary Concept]
- butyroyloxymethyl 4-phenylbutyrate [MeSH Supplementary Concept]
- cyclic hydroxamic acid-containing peptide 1 [MeSH Supplementary Concept]
- metacept-1 [MeSH Supplementary Concept]
- pimelic diphenylamide 106 [MeSH Supplementary Concept]
- scriptide [MeSH Supplementary Concept]
- tert-butyl 7-(2-(hydroxyamino)-2-oxoethoxy)-3-(4-methoxyphenylcarbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate [MeSH Supplementary Concept]
- thioisobutyric acid S-(6-(4-phenyl-2-thiazolylcarbamoyl)hexyl) ester [MeSH Supplementary Concept]
- triciferol [MeSH Supplementary Concept]
- tubastatin A [MeSH Supplementary Concept]
Record concept(s)
- class I histone deacetylases [MeSH concept]
- class II histone deacetylases [MeSH concept]
- histone deacetylase complexes [MeSH concept]
- histone deacetylases [MeSH concept]
Related MeSH Supplementary Concept(s)
- AT5G63110 protein, Arabidopsis [MeSH Supplementary Concept]
- Dep1 protein, S cerevisiae [MeSH Supplementary Concept]
- HD2C protein, arabidopsis [MeSH Supplementary Concept]
- HDA-1 protein, C elegans [MeSH Supplementary Concept]
- HDA-4 protein, C elegans [MeSH Supplementary Concept]
- HDA1 protein, S cerevisiae [MeSH Supplementary Concept]
- HDA15 protein, arabidopsis [MeSH Supplementary Concept]
- HDA18 protein, arabidopsis [MeSH Supplementary Concept]
- HDA19 protein, arabidopsis [MeSH Supplementary Concept]
- HDA5 protein, Arabidopsis [MeSH Supplementary Concept]
- HDA9 protein, arabidopsis [MeSH Supplementary Concept]
- HDAC10 protein, human [MeSH Supplementary Concept]
- HDAC11 protein, drosophila [MeSH Supplementary Concept]
- HDAC11 protein, human [MeSH Supplementary Concept]
- HDAC3 protein, zebrafish [MeSH Supplementary Concept]
- HDAC4 protein, drosophila [MeSH Supplementary Concept]
- HDAC4 protein, human [MeSH Supplementary Concept]
- HDAC4 protein, rat [MeSH Supplementary Concept]
- HDAC4 protein, zebrafish [MeSH Supplementary Concept]
- HDAC5 protein, human [MeSH Supplementary Concept]
- HDAC5 protein, zebrafish [MeSH Supplementary Concept]
- HDAC6 protein, drosophila [MeSH Supplementary Concept]
- HDAC6 protein, human [MeSH Supplementary Concept]
- HDAC6 protein, rat [MeSH Supplementary Concept]
- HDAC6 protein, zebrafish [MeSH Supplementary Concept]
- HDAC7 protein, human [MeSH Supplementary Concept]
- HDAC7 protein, rat [MeSH Supplementary Concept]
- HDAC8 protein, human [MeSH Supplementary Concept]
- HDAC8 protein, mouse [MeSH Supplementary Concept]
- HDAC8 protein, zebrafish [MeSH Supplementary Concept]
- HDAC9 protein, human [MeSH Supplementary Concept]
- HDAC9 protein, rat [MeSH Supplementary Concept]
- HDF1 protein, fusarium graminearum [MeSH Supplementary Concept]
- HDT1 protein, arabidopsis [MeSH Supplementary Concept]
- HDT2 protein, arabidopsis [MeSH Supplementary Concept]
- HDT4 protein, Arabidopsis [MeSH Supplementary Concept]
- HOS2 protein, S cerevisiae [MeSH Supplementary Concept]
- Hd1 protein, arabidopsis [MeSH Supplementary Concept]
- Hdac11 protein, mouse [MeSH Supplementary Concept]
- Hdac3 protein, drosophila [MeSH Supplementary Concept]
- Hdac5 protein, mouse [MeSH Supplementary Concept]
- Hdac5 protein, rat [MeSH Supplementary Concept]
- Hdac6 protein, mouse [MeSH Supplementary Concept]
- Hdac7 protein, mouse [MeSH Supplementary Concept]
- Hdac8 protein, rat [MeSH Supplementary Concept]
- Hdac9 protein, mouse [MeSH Supplementary Concept]
- Hos3 protein, S cerevisiae [MeSH Supplementary Concept]
- Hst3 protein, S cerevisiae [MeSH Supplementary Concept]
- Hst4 protein, S cerevisiae [MeSH Supplementary Concept]
- Hst4 protein, S pombe [MeSH Supplementary Concept]
- MTA2 protein, human [MeSH Supplementary Concept]
- MeCP1 histone deacetylase complex, human [MeSH Supplementary Concept]
- MeCP1 histone deacetylase complex, mouse [MeSH Supplementary Concept]
- MeCP1 histone deacetylase complex, rat [MeSH Supplementary Concept]
- Mta1 protein, human [MeSH Supplementary Concept]
- PHF21A protein, human [MeSH Supplementary Concept]
- Phf21a protein, mouse [MeSH Supplementary Concept]
- RPD3 protein, S cerevisiae [MeSH Supplementary Concept]
- Raf60 protein, S cerevisiae [MeSH Supplementary Concept]
- Rv115c protein, Mycobacterium tuberculosis [MeSH Supplementary Concept]
- Rxt2 protein, S cerevisiae [MeSH Supplementary Concept]
- SAP25 protein, mouse [MeSH Supplementary Concept]
- SAP30 protein, S cerevisiae [MeSH Supplementary Concept]
- SAP30 protein, human [MeSH Supplementary Concept]
- SDS3 protein, S cerevisiae [MeSH Supplementary Concept]
- SIF2 protein, Arabidopsis [MeSH Supplementary Concept]
- SIF2 protein, S cerevisiae [MeSH Supplementary Concept]
- SIN3 protein, S cerevisiae [MeSH Supplementary Concept]
- SNT1 protein, S cerevisiae [MeSH Supplementary Concept]
- Sap18 protein, mouse [MeSH Supplementary Concept]
- Sap30 protein, mouse [MeSH Supplementary Concept]
- Set3 protein, S cerevisiae [MeSH Supplementary Concept]
- Sirt2 protein, Drosophila [MeSH Supplementary Concept]
- flowering locus D protein, arabidopsis [MeSH Supplementary Concept]
- hdac10 protein, zebrafish [MeSH Supplementary Concept]
- hdac9-A protein, xenopus [MeSH Supplementary Concept]
- histone deacetylase 14, Arabidopsis [MeSH Supplementary Concept]
- histone deacetylase 3 [MeSH Supplementary Concept]
Related MeSH term(s)
- histone deacetylase inhibitors [MeSH Descriptor]
See also (suggested by CISMeF)
- sirtuins [MeSH Descriptor]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- Histone Deacetylase [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients