sirtuins - CISMeF

Preferred Label : sirtuins;

MeSH definition : A homologous family of regulatory enzymes that are structurally related to the protein silent mating type information regulator 2 (Sir2) found in Saccharomyces cerevisiae. Sirtuins contain a central catalytic core region which binds NAD. Several of the sirtuins utilize NAD to deacetylate proteins such as HISTONES and are categorized as GROUP III HISTONE DEACETYLASES. Several other sirtuin members utilize NAD to transfer ADP-RIBOSE to proteins and are categorized as MONO ADP-RIBOSE TRANSFERASES, while a third group of sirtuins appears to have both deacetylase and ADP ribose transferase activities.;

MeSH synonym : silent mating type information regulator 2 like proteins; sir2-like proteins; silent mating type information regulator 2-like proteins; sir2 like proteins; SIRTs; SIRT; Sirtuin;

CISMeF synonym : deacetylases, nad-dependent protein; nad-dependent protein deacetylases; nad dependent protein deacetylases; protein deacetylases, nad-dependent;

Registry Number MeSH : EC 3.5.1.-;

Wikipedia link : https://en.wikipedia.org/wiki/Sirtuin;

Is substance : O;

Details

Origin ID

D037761;

UMLS CUI

C1136177;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- NAD-Dependent Deacetylase Sirtuin-3, Mitochondrial [NCIt concept]
- NAD-Dependent Protein Deacetylase Sirtuin-1 [NCIt concept]
- Selective Internal Radiation Therapy [NCIt concept]
Indexing information
- sirtinol [MeSH Supplementary Concept]
Record concept(s)
- sirtuins [MeSH concept]
Related MeSH Supplementary Concept(s)
- SIR-2.1 protein, C elegans [MeSH Supplementary Concept]
- SIRT3 protein, rat [MeSH Supplementary Concept]
- SIRT4 protein, human [MeSH Supplementary Concept]
- SIRT4 protein, mouse [MeSH Supplementary Concept]
- SIRT5 protein, human [MeSH Supplementary Concept]
- SIRT5 protein, mouse [MeSH Supplementary Concept]
- SIRT5 protein, rat [MeSH Supplementary Concept]
- SIRT6 protein, human [MeSH Supplementary Concept]
- SIRT7 protein, human [MeSH Supplementary Concept]
- SIRT7 protein, rat [MeSH Supplementary Concept]
- SRT2 protein, Arabidopsis [MeSH Supplementary Concept]
- Sir2 protein, kluyveromyces lactis [MeSH Supplementary Concept]
- Sirt2 protein, Drosophila [MeSH Supplementary Concept]
- Sirt6 protein, mouse [MeSH Supplementary Concept]
- Sirt7 protein, mouse [MeSH Supplementary Concept]
- cobB protein, E coli [MeSH Supplementary Concept]
- sir-2.3 protein, C elegans [MeSH Supplementary Concept]
- sirtuin 6, rat [MeSH Supplementary Concept]
See also
- silent information regulator proteins, saccharomyces cerevisiae [MeSH Descriptor]
See also (suggested by CISMeF)
- histone deacetylases [MeSH Descriptor]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]

Keyword's position in hierarchy(ies) :

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