Belinostat - CISMeF

Preferred Label : Belinostat;

NCIt related terms : PXD 101; PXD101;

NCIt definition : A novel hydroxamic acid-type histone deacetylase (HDAC) inhibitor with antineoplastic activity. Belinostat targets HDAC enzymes, thereby inhibiting tumor cell proliferation, inducing apoptosis, promoting cellular differentiation, and inhibiting angiogenesis. This agent may sensitize drug-resistant tumor cells to other antineoplastic agents, possibly through a mechanism involving the down-regulation of thymidylate synthase.;

Alternative definition : NCI-GLOSS: A substance being studied in the treatment of cancer. Belinostat blocks enzymes needed for cell division and may kill cancer cells. It also prevents the growth of blood vessels needed for tumors to grow and may make tumor cells more sensitive to other anticancer drugs. It is a type of histone deacetylase (HDAC) inhibitor, a type of angiogenesis inhibitor, and a type of chemosensitizer.;

UNII : F4H96P17NZ;

InChIKey : NCNRHFGMJRPRSK-MDZDMXLPSA-N;

CAS number : 414864-00-9; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 414864-00-9 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Beleodaq;

Molecule name : PXD 101; PXD101;

Chemical formula : C15H14N2O4S;

NSC code : 726630;

ChEBI ID : CHEBI:61076;

Codes from synonyms : CDR0000486423; CDR0000600484; 32043; 63;

Details

Origin ID

C48812;

UMLS CUI

C1948068;

Automatic exact mappings (from CISMeF team)
- Belinostat [ICD-11 More detail]
- belinostat [ATC Code]
CISMeF manual mappings
- Belinostat (substance) [SNOMED CT concept]
Currated CISMeF NLP mapping
- belinostat [MeSH Supplementary Concept]
- belinostat [MeSH concept]
See also inter- (CISMeF)
- Product containing belinostat (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Belinostat (substance) [SNOMED CT concept]
- Product containing belinostat (medicinal product) [SNOMED CT concept]
- belinostat [ATC Code]
- belinostat [MeSH concept]
- belinostat [MeSH Supplementary Concept]
chemical_or_drug_has_mechanism_of_action
- Enzyme Inhibition [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Negative Regulation of Angiogenesis [NCIt concept]
- Positive Regulation of Apoptosis [NCIt concept]
- Positive Regulation of Cell Differentiation [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Histone Deacetylase [NCIt concept]
is_component_of_chemotherapy_regimen
- Belinostat Regimen [NCIt concept]

Keyword's position in hierarchy(ies) :

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