NCIt definition : A novel hydroxamic acid-type histone deacetylase (HDAC) inhibitor with antineoplastic
activity. Belinostat targets HDAC enzymes, thereby inhibiting tumor cell proliferation,
inducing apoptosis, promoting cellular differentiation, and inhibiting angiogenesis.
This agent may sensitize drug-resistant tumor cells to other antineoplastic agents,
possibly through a mechanism involving the down-regulation of thymidylate synthase.;
Alternative definition : NCI-GLOSS: A substance being studied in the treatment of cancer. Belinostat blocks
enzymes needed for cell division and may kill cancer cells. It also prevents the growth
of blood vessels needed for tumors to grow and may make tumor cells more sensitive
to other anticancer drugs. It is a type of histone deacetylase (HDAC) inhibitor, a
type of angiogenesis inhibitor, and a type of chemosensitizer.;
UNII : F4H96P17NZ;
InChIKey : NCNRHFGMJRPRSK-MDZDMXLPSA-N;
CAS number : 414864-00-9;
Drug name : Beleodaq;
Molecule name : PXD 101; PXD-101;
Chemical formula : C15H14N2O4S;
NSC code : 726630;
ChEBI ID : CHEBI:61076;
Codes from synonyms : CDR0000486423; CDR0000600484; 32043; 63;