Preferred Label : Abexinostat;
NCIt synonyms : HDAC Inhibitor CRA-024781; HDAC Inhibitor PCI-24781; 3-((dimethylamino)methyl)-N-(2-(4-(hydroxycarbamoyl)phenoxy)ethyl)-1-benzofuran-2-carboxamide; 2-benzofurancarboxamide, 3-((dimethylamino)methyl)-n-(2-(4-((hydroxyamino)carbonyl)phenoxy)ethyl)-;
NCIt related terms : CRA-024781;
NCIt definition : An orally bioavailable hydroxamate-based pan-inhibitor of histone deacetylase (HDAC),
with potential antineoplastic and radiosensitizing activities. Upon administration,
abexinostat inhibits HDAC, resulting in an accumulation of highly acetylated histones,
followed by the induction of chromatin remodeling; the selective transcription of
tumor suppressor genes; and the tumor suppressor protein-mediated inhibition of tumor
cell division and induction of tumor cell apoptosis. In addition, abexinostat decreases
the expression of the DNA-repair protein RAD51, thereby reducing the RAD51 protein,
preventing repair of DNA double-strand breaks and increasing sensitivity of tumor
cells to DNA damaging agents. HDAC, upregulated in many tumor types, is an enzyme
that is responsible for the deacetylation of chromatin histone proteins.;
Alternative definition : NCI-GLOSS: A substance being studied in the treatment of several types of cancer.
It blocks enzymes needed for cell division and may kill cancer cells. It is a type
of histone deacetylase (HDAC) inhibitor.;
UNII : IYO470654U;
InChIKey : MAUCONCHVWBMHK-UHFFFAOYSA-N;
CAS number : 783355-60-2;
Molecule name : CRA-024781; PCI-24781; PCI 24781;
Chemical formula : C21H23N3O5;
Codes from synonyms : CDR0000630936; 5;
Origin ID : C68920;
UMLS CUI : C3537177;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- has_salt_form
- has_target
- is_free_acid_or_base_form_of
