HDAC Inhibitor REC-2282

Preferred Label : HDAC Inhibitor REC-2282;

NCIt synonyms : (S)-N-hydroxy-4-(3-methyl-2-phenylbutanamido)benzamide;

NCIt related terms : REC-2282;

NCIt definition : An orally available phenylbutyrate-derived histone deacetylase (HDAC) inhibitor, with potential antineoplastic activity. Upon oral administration, REC-2282 inhibits the catalytic activity of HDAC, which results in an accumulation of highly acetylated chromatin histones, the induction of chromatin remodeling and an altered pattern of gene expression. This leads to the inhibition of tumor oncogene transcription, and the selective transcription of tumor suppressor genes, which inhibits tumor cell division and induces tumor cell apoptosis. HDAC, an enzyme upregulated in many tumor types, deacetylates chromatin histone proteins.;

UNII : E0GG29V0AQ;

CAS number : 935881-37-1;

Molecule name : AR-42; OSU-HDAC42; HDAC-42; REC-2282;

Details

Origin ID

C116850;

UMLS CUI

C5666846;

Currated CISMeF NLP mapping
- HDAC-42 [MeSH Supplementary Concept]
- HDAC-42 [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- HDAC-42 [MeSH Supplementary Concept]
- HDAC-42 [MeSH concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Histone Deacetylase [NCIt concept]

Keyword's position in hierarchy(ies) :

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