Tributyrin - CISMeF

Preferred Label : Tributyrin;

NCIt synonyms : Butyryl Triglyceride; Glyceryl Tributyrate; 1,2,3-Propanetriyl Butanoate; Butanoic Acid 1,2,3-Propanetriyl Ester; TB;

NCIt related terms : Butanoic Acid, 1,2,3-Propanetriyl Ester; 1,2,3-Tributyrylglycerol;

NCIt definition : A triglyceride prodrug of butyric acid with potential antineoplastic activity. Butyrate, the active metabolite of tributyrin, inhibits histone deacetylase, resulting in increased differentiation, decreased proliferation, cell cycle arrest, and apoptosis in some tumor cell lines. (NCI04);

Alternative definition : NCI-GLOSS: A triglyceride drug that may inhibit cell growth and induce cell differentiation. Differentiating agents may be effective in changing cancer cells back into normal cells.;

UNII : S05LZ624MF;

InChIKey : UYXTWWCETRIEDR-UHFFFAOYSA-N;

CAS number : 60-01-5;

Chemical formula : C15H26O6;

NSC code : 661583;

Codes from synonyms : 04044; NSC0661583; CDR0000045443;

Details

Origin ID

C1260;

UMLS CUI

C0077025;

Automatic exact mappings (from CISMeF team)
- Tuberculosis [Bloc CIM-11]
- mycobacterium tuberculosis [MeSH Descriptor]
- tuberculosis [MeSH Descriptor]
- tuberculosis [Radlex concept]
Currated CISMeF NLP mapping
- glycerol tributyrate [Substance BNPC]
- tributyrin [MeSH concept]
- tributyrin [MeSH Supplementary Concept]
False automatic mappings
- Townes-brocks syndrome 1 [OMIM Phenotype]
- Transmitted by (attribute) [SNOMED CT concept]
- Tuberculosis [MedDRA Preferred Term]
- tuberculosis [MedlinePlus Topic]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- glycerol tributyrate [Substance BNPC]
- tributyrin [MeSH concept]
- tributyrin [MeSH Supplementary Concept]
chemical_or_drug_affects_gene_product
- Histone Deacetylase [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Enzyme Inhibition [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Histone Deacetylation [NCIt concept]
- Inhibition of Cell Proliferation [NCIt concept]
- Negative Regulation of Cell Cycle [NCIt concept]
- Positive Regulation of Cell Differentiation [NCIt concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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