Preferred Label : Bocodepsin Besylate;
NCIt synonyms : HDACi 1/4 OKI-179; HDAC Inhibitor OKI-179; HDACi OKI-179; Class-1/4 HDACi OKI-179; HDAC1/4i OKI-179; Class 1/4 Histone Deacetylase Inhibitor OKI-179;
NCIt definition : The besylate form of bocodepsin, an orally bioavailable inhibitor of the histone deacetylase
(HDAC) subtypes 1 and 4, with potential antineoplastic activity. Upon administration,bocodepsin
targets, binds to and inhibits the activity of HDAC1/4. This results in an accumulation
of highly acetylated chromatin histones, the induction of chromatin remodeling and
an altered pattern of gene expression. This consequently results in a selective transcription
of tumor suppressor genes, tumor suppressor protein-mediated inhibition of tumor cell
division and an induction of apoptosis in tumor cells that overexpress HDAC1/4. HDAC,
which is upregulated in many tumor cell types, deacetylates chromatin histone proteins
and plays a key role in transcriptional regulation and cell cycle progression.;
UNII : LVM50TS2UO;
CAS number : 1834513-67-5;
Molecule name : OKI-179; OKI 179;
NCI Metathesaurus CUI : CL969661;
Origin ID : C160606;
UMLS CUI : C5205394;
Semantic type(s)
- concept_is_in_subset
- has_target
