Arginine Butyrate

Preferred Label : Arginine Butyrate;

NCIt synonyms : L-Arginine, Butanoate (3:4); SCFA HQK-1004; Short Chain Fatty Acid HQK-1004;

NCIt definition : A compound composed of the short chain fatty acid (SCFA) butyrate combined with the amino acid arginine, with potential Epstein-Barr virus thymidine kinase gene (EBV-TK)-inducing activity. Upon administration, arginine butyrate induces the expression of thymidine kinase (TK). This activates a co-administered antiviral, such as ganciclovir, and results in the destruction of EBV-infected cancer cells. In addition, butyrate inhibits histone deacetylase (HDAC), which results in hyperacetylation of histones H3 and H4. Acetylated histones have a reduced affinity for chromatin; this reduced histone-chromatin affinity may allow chromosomal unfolding, potentially enhancing the expression of genes related to tumor cell growth arrest and apoptosis.;

Alternative definition : NCI-GLOSS: A substance that is being studied as a treatment for cancer.;

UNII : IK8S1P79MU;

InChIKey : ZVEMACCDKBQNGX-KALODSIISA-N;

CAS number : 80407-72-3;

Molecule name : VX-105; HQK-1004;

Chemical formula : 3C6H14N4O2.4C4H8O2;

Codes from synonyms : 30607; CDR0000045494;

Details

Origin ID

C2570;

UMLS CUI

C0052329;

Currated CISMeF NLP mapping
- Arginine butyrate [SMS substance]
- arginine butyrate [MeSH concept]
- arginine butyrate [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- arginine butyrate [MeSH concept]
- arginine butyrate [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Histone Deacetylase [NCIt concept]
is_component_of_chemotherapy_regimen
- Arginine butyrate/Ganciclovir [NCIt concept]

Keyword's position in hierarchy(ies) :

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