Preferred Label : Panobinostat Nanoparticle Formulation MTX110;
NCIt definition : A gold nanoparticle (GNP)-based formulation containing panobinostat, a pan histone
deacetylase (HDAC) inhibitor, with potential antineoplastic activity. Upon intra-tumoral
injection of MTX110, panobinostat is released from the formulation and selectively
targets, binds to and inhibits histone deacetylase (HDAC), which induces hyperacetylation
of core histone proteins. The accumulation of highly acetylated histones leads to
chromatin remodeling, an altered pattern of gene expression, inhibition of tumor oncogene
transcription and the selective transcription of tumor suppressor genes. This results
in the inhibition of tumor cell division and the induction of tumor cell apoptosis.
HDAC, upregulated in many tumor cell types, is an enzyme family that deacetylates
histone proteins. Panobinostat is water insoluble and does not cross the blood-brain
barrier (BBB) when administered orally or intravenously. MTX110 solubilizes panobinostat
and can be directly injected into the brain, which bypasses the BBB and delivers high
concentrations of panobinostat to the tumor, while minimizing systemic toxicity.;
Molecule name : MTX-110; MTX 110;
NCI Metathesaurus CUI : CL552518;
Origin ID : C150717;
UMLS CUI : C4725946;
Semantic type(s)
- concept_is_in_subset
- has_target
