Preferred Label : Purinostat Mesylate;
NCIt definition : The mesylate salt form of purinostat, an inhibitor of histone deacetylase (HDAC) classes
I and IIb, with potential antineoplastic activities. Upon administration, purinostat
selectively inhibits the catalytic activity of class I and IIb HDACs, which results
in an accumulation of highly acetylated chromatin histones, the induction of chromatin
remodeling and an altered pattern of gene expression. This leads to the inhibition
of tumor oncogene transcription, and the selective transcription of tumor suppressor
genes, which inhibits tumor cell division and induces tumor cell apoptosis. HDAC,
an enzyme upregulated in many tumor types, deacetylates chromatin histone proteins.
Class I HDACs are located in the nucleus and include HDACs 1, 2, 3, and 8; class IIb
HDACs include HDAC 6 and 10 and are located in both the nucleus and the cytoplasm.;
UNII : WP897GX44U;
NCI Metathesaurus CUI : CL1905573;
Origin ID : C192177;
UMLS CUI : C5784962;
Semantic type(s)
- concept_is_in_subset
- has_free_acid_or_base_form
- has_target
- is_salt_form_of
