Preferred Label : Purinostat;
NCIt definition : An inhibitor of histone deacetylase (HDAC) classes I and IIb, with potential antineoplastic
activities. Upon administration, purinostat selectively inhibits the catalytic activity
of class I and IIb HDACs, which results in an accumulation of highly acetylated chromatin
histones, the induction of chromatin remodeling and an altered pattern of gene expression.
This leads to the inhibition of tumor oncogene transcription, and the selective transcription
of tumor suppressor genes, which inhibits tumor cell division and induces tumor cell
apoptosis. HDAC, an enzyme upregulated in many tumor types, deacetylates chromatin
histone proteins. Class I HDACs are located in the nucleus and include HDACs 1, 2,
3, and 8; class IIb HDACs include HDAC 6 and 10 and are located in both the nucleus
and the cytoplasm.;
UNII : FTV8V4AYQ8;
CAS number : 1929583-17-4;
NCI Metathesaurus CUI : CL1905572;
Origin ID : C192176;
UMLS CUI : C5784961;
Semantic type(s)
- concept_is_in_subset
- has_salt_form
- is_free_acid_or_base_form_of
