Tefinostat - CISMeF

Preferred Label : Tefinostat;

NCIt definition : A hydroxamic acid-derived histone deacetylase (HDAC) inhibitor with potential antineoplastic activity. Tefinostat inhibits HDAC leading to an accumulation of highly acetylated histones, which may result in chromatin remodeling, inhibition of tumor oncogene transcription, inhibition of tumor cell division, and the induction of tumor cell apoptosis. HDAC, an enzyme upregulated in many tumor types, deacetylates chromatin histone proteins; this agent may specifically target HDACs in cells of the monocyte-macrophage lineage.;

UNII : ZAU91150SB;

InChIKey : GLNWREBYRLDPQP-MHZLTWQESA-N;

CAS number : 914382-60-8;

Molecule name : CHR-2845; CHR 2845;

Details

Origin ID

C152539;

UMLS CUI

C3714116;

Automatic exact mappings (from CISMeF team)
- CHR 2845 [MeSH Supplementary Concept]
- tefinostat [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- tefinostat [MeSH concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Histone Deacetylase [NCIt concept]

Keyword's position in hierarchy(ies) :

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