Preferred Label : HDAC8 Inhibitor NBM-BMX;
NCIt synonyms : HDAC8i NBM-BMX;
NCIt definition : An orally bioavailable inhibitor of histone deacetylase (HDAC) type 8 (HDAC8; HDAC-8),
with potential antineoplastic activity. Upon administration, NBM-BMX targets and inhibits
the activity of HDAC8. This results in an accumulation of highly acetylated chromatin
histones, chromatin remodeling, and selective transcription of tumor suppressor genes,
ultimately promoting cell-cycle arrest and induction of tumor cell apoptosis. HDAC8,
a class 1 histone deacetylase, plays a key role in transcriptional regulation and
cell cycle progression. Aberrant expression of HDAC8 or deregulated interactions with
transcription factors may contribute to tumorigenesis. Isotype-selective HDAC inhibitors
may be associated with fewer adverse effects compared to pan-HDAC inhibitors.;
Molecule name : NBM-BMX; NBM BMX;
NCI Metathesaurus CUI : CL951454;
Origin ID : C159496;
UMLS CUI : C5204484;
Semantic type(s)
- concept_is_in_subset
- has_target
