Preferred Label : Bisthianostat;
NCIt definition : An orally bioavailable pan-inhibitor of human histone deacetylase (HDAC), with potential
antineoplastic activity. Upon administration, bisthianostat selectively binds to and
inhibits HDACs, which inhibits deacetylation of histone proteins and leads to the
accumulation of highly acetylated histones. This may result in an induction of chromatin
remodeling, the inhibition of tumor oncogene transcription, and the selective transcription
of tumor suppressor genes. This prevents cell division, induces cell cycle arrest
and apoptosis. This may inhibit the proliferation of susceptible tumor cells. HDACs,
upregulated in many tumor cell types, are a family of enzymes that deacetylate histone
proteins.;
Molecule name : CFH367 C; CFH367-C; PY-1; CF367;
NCI Metathesaurus CUI : CL977258;
Origin ID : C163996;
UMLS CUI : C5235882;
Semantic type(s)
- concept_is_in_subset
- has_target
