Preferred Label : Zabadinostat;
NCIt synonyms : Histone Deacetylase Inhibitor CXD101; HDAC Inhibitor CXD101;
NCIt definition : A novel histone deacetylase (HDAC) inhibitor with potential antineoplastic activity.
Although the exact therapeutic mechanism of action for CXD101 is not known, oral administration
of this agent should inhibit the catalytic activity of HDAC, which results in an accumulation
of highly acetylated histones, followed by the induction of chromatin remodeling and
an altered pattern of gene expression. HDAC, a family of enzymes upregulated in many
tumor types, deacetylates chromatin-associated histone proteins.;
UNII : 5TNV87ICD2;
InChIKey : JHDZMASHNBKTPS-UHFFFAOYSA-N;
CAS number : 934828-12-3; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 934828-12-3
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G-SRS /a ;
Molecule name : AZD 9468; AZD9468; CXD101;
NCI Metathesaurus CUI : CL454389;
Origin ID : C112177;
UMLS CUI : C3827064;
Semantic type(s)
- concept_is_in_subset
- has_target
