" /> Entinostat - CISMeF





Preferred Label : Entinostat;

NCIt synonyms : N-(2-Aminophenyl)-4-[N-(pyridin-3-yl-methoxycarbonyl)aminomethyl]b enzamide; Carbamic Acid, N-[[4-[[(2-aminophenyl)amino]carbonyl]phenyl]methyl]-, 3- pyridinylmethyl Ester; Carbamic acid, [[4-[[(2-aminophenyl)amino]carbonyl]phenyl] methyl]-, 3-pyridinylmethyl ester (9CI); MS-27-275;

NCIt related terms : HDAC inhibitor SNDX-275; MS-275; SNDX-275;

NCIt definition : A synthetic benzamide derivative with potential antineoplastic activity. Entinostat binds to and inhibits histone deacetylase, an enzyme that regulates chromatin structure and gene transcription. This agent appears to exert dose-dependent effects in human leukemia cells including cyclin-dependent kinase inhibitor 1A (p21/CIP1/WAF1)-dependent growth arrest and differentiation at low drug concentrations; a marked induction of reactive oxygen species (ROS); mitochondrial damage; caspase activation; and, at higher concentrations, apoptosis. In normal cells, cyclin-dependent kinase inhibitor 1A expression has been associated with cell-cycle exit and differentiation.;

Alternative definition : NCI-GLOSS: A substance being studied in the treatment of several types of cancer. It blocks enzymes needed for cell division and may kill cancer cells. It is a type of histone deacetylase (HDAC) inhibitor.;

UNII : 1ZNY4FKK9H;

InChIKey : INVTYAOGFAGBOE-UHFFFAOYSA-N;

CAS number : 209783-80-2;

Molecule name : MS 27-275; MS-275; SNDX-275; SNDX 275; MS 275;

Chemical formula : C21H20N4O3;

NSC code : 706995;

Codes from synonyms : 31823; CDR0000630957; CDR0000630959; CDR0000045014; CDR0000635095; 186;

Details


Keyword's position in hierarchy(ies) : arborescence

You can consult :


Nous contacter.
08/05/2025


[Home] [Top]

© Rouen University Hospital. Any partial or total use of this material must mention the source.