Entinostat - CISMeF

Preferred Label : Entinostat;

NCIt synonyms : N-(2-Aminophenyl)-4-[N-(pyridin-3-yl-methoxycarbonyl)aminomethyl]b enzamide; Carbamic Acid, N-[[4-[[(2-aminophenyl)amino]carbonyl]phenyl]methyl]-, 3- pyridinylmethyl Ester; Carbamic acid, [[4-[[(2-aminophenyl)amino]carbonyl]phenyl] methyl]-, 3-pyridinylmethyl ester (9CI); MS-27-275;

NCIt related terms : HDAC inhibitor SNDX-275; MS-275; SNDX-275;

NCIt definition : A synthetic benzamide derivative with potential antineoplastic activity. Entinostat binds to and inhibits histone deacetylase, an enzyme that regulates chromatin structure and gene transcription. This agent appears to exert dose-dependent effects in human leukemia cells including cyclin-dependent kinase inhibitor 1A (p21/CIP1/WAF1)-dependent growth arrest and differentiation at low drug concentrations; a marked induction of reactive oxygen species (ROS); mitochondrial damage; caspase activation; and, at higher concentrations, apoptosis. In normal cells, cyclin-dependent kinase inhibitor 1A expression has been associated with cell-cycle exit and differentiation.;

Alternative definition : NCI-GLOSS: A substance being studied in the treatment of several types of cancer. It blocks enzymes needed for cell division and may kill cancer cells. It is a type of histone deacetylase (HDAC) inhibitor.;

UNII : 1ZNY4FKK9H;

InChIKey : INVTYAOGFAGBOE-UHFFFAOYSA-N;

CAS number : 209783-80-2; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 209783-80-2 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : MS 27-275; MS-275; SNDX-275;

Chemical formula : C21H20N4O3;

NSC code : 706995;

Codes from synonyms : 31823; CDR0000630957; CDR0000630959; CDR0000045014; CDR0000635095; 186;

Details

Origin ID

C1863;

UMLS CUI

C2743752;

Automatic exact mappings (from CISMeF team)
- Entinostat [ICD-11 Extension code]
- entinostat [ATC Code]
Currated CISMeF NLP mapping
- entinostat [MeSH concept]
- entinostat [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- entinostat [MeSH Supplementary Concept]
- entinostat [ATC Code]
- entinostat [MeSH concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Histone Deacetylase [NCIt concept]

Keyword's position in hierarchy(ies) :

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