NCIt definition : An orally bioavailable inhibitor of both phosphoinositide 3-kinase (PI3K) class I
and pan histone deacetylase (HDAC) enzymes, with potential antineoplastic activity.
Upon oral administration, fimepinostat inhibits the activity of both PI3K class I
isoforms and HDAC, thereby preventing the activation of the PI3K-AKT-mTOR signal transduction
pathway that is often overactivated in many cancer cell types. This may prevent growth
of PI3K and/or HDAC-expressing tumor cells. CUDC-907 shows an increased inhibition
of tumor cell growth and induction of apoptosis when compared to inhibitors that target
either PI3K or HDAC.;